U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction

@article{Sashital2004U2U6RF,
  title={U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction},
  author={Dipali G Sashital and Gabriel Cornilescu and Samuel E Butcher},
  journal={Nature Structural &Molecular Biology},
  year={2004},
  volume={11},
  pages={1237-1242}
}
Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis of a protein-free U2–U6 complex from Saccharomyces cerevisiae. The observed folding of the U2–U6 complex is a four-helix junction, in which the catalytically important AGC triad base-pairs only within… CONTINUE READING
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Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif

  • Sigel, R.K
  • Nat. Struct. Mol. Biol
  • 2004

Structural basis for a lethal mutation in U 6 RNA

  • C. D. Schwieters, J. J. Kuszewski, N. Tjandra, G. Marius Clore
  • Biochemistry
  • 2003

Structural basis for a lethal mutation in U6

  • D. G. Sashital, A. M. Allmann, S. R. Van Doren, S. E. Butcher
  • RNA. Biochemistry
  • 2003

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