U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases.

@article{Koh2006U18666AmediatedAI,
  title={U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases.},
  author={Chor Hui Vivien Koh and Robert Z. Qi and Dianbo Qu and Alirio J. Melendez and Jayapal Manikandan and Boon-Huat Bay and Wei Duan and Nam Sang Cheung},
  journal={Cellular signalling},
  year={2006},
  volume={18 10},
  pages={1572-83}
}
Studies have suggested that cholesterol imbalance in the brain might be related to the development of neurological disorders such as Alzheimer's disease and Niemann-Pick disease type C. Previously, we have reported that U18666A, a cholesterol transport-inhibiting agent, leads to apoptosis and intracellular cholesterol accumulation in primary cortical neurons. In this study, we examined the effects of U18666A-mediated neuronal apoptosis, and found that chronic exposure to U18666A led to the… CONTINUE READING