U1 snRNP Determines mRNA Length and Regulates Isoform Expression

  title={U1 snRNP Determines mRNA Length and Regulates Isoform Expression},
  author={Michael G. Berg and Larry N. Singh and Ihab Younis and Qiang Liu and Anna Maria Pinto and Daisuke Kaida and Zhenxi Zhang and Sungchan Cho and Scott Sherrill-Mix and Lili Wan and Gideon Dreyfuss},
U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic premature termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation signals (PASs) in introns. Here, a high-throughput sequencing strategy of differentially expressed transcripts (HIDE-seq) mapped PCPA sites genome wide in divergent organisms. Surprisingly, whereas U1 depletion terminated most nascent gene transcripts within ~1 kb, moderate functional U1 level decreases, insufficient to inhibit… CONTINUE READING
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