U1 snRNA associates with TFIIH and regulates transcriptional initiation

@article{Kwek2002U1SA,
  title={U1 snRNA associates with TFIIH and regulates transcriptional initiation},
  author={Kon Yew Kwek and Shona Murphy and Andr{\'e} Furger and Benjamin Thomas and William E O'Gorman and Hiroshi Kimura and Nicholas J. Proudfoot and Alexandre Akoulitchev},
  journal={Nature Structural Biology},
  year={2002},
  volume={9},
  pages={800-805}
}
Diverse classes of noncoding RNA, including small nuclear RNAs (snRNAs), play fundamental regulatory roles at many stages of gene expression. For example, recent studies have implicated 7SK RNA and components of the splicing apparatus in the regulation of transcriptional elongation. Here we present the first evidence of the involvement of an snRNA in the regulation of transcriptional initiation. We demonstrate that TFIIH, a general transcription initiation factor, specifically associates with… 
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