U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.

@article{Hotokezaka2002U0126AP,
  title={U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.},
  author={Hitoshi Hotokezaka and Eiko Sakai and Kazuhiro Kanaoka and Kan Saito and Ken-ichiro Matsuo and Hideki Kitaura and Noriaki Yoshida and Koji Nakayama},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={
          47366-72
        }
}
Osteoclasts are multinucleated cells that differentiate from hematopoietic cells and possess characteristics responsible for bone resorption. To study the involvement of mitogen-activated protein kinases (MAPKs) in osteoclastogenesis of the murine monocytic cell line RAW264.7, which can differentiate into osteoclast-like cells in the presence of the receptor activator of nuclear factor kappa B ligand (RANKL), we treated the cells with specific inhibitors of p38 MAPK, PD169316 and SB203580, and… CONTINUE READING
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