U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in mice

@article{Wall2000U69593MI,
  title={U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in mice},
  author={Philip M. Wall and Claude Messier},
  journal={Brain Research},
  year={2000},
  volume={856},
  pages={259-280}
}
The present report investigated the contributions of the ventromedial prefrontal cortex to the control of spontaneous alternation/working memory and anxiety-related behaviour. In Experiment 1, we examined the effects of microinjections of the selective kappa(1) receptor agonist, U-69,593, in the infralimbic cortex (IL) of CD-1 mice on several ethologically-derived anxiety indices in the elevated plus-maze (EPM) and defensive/withdrawal (D/W) anxiety in the open field, as well as on memory in… 
Concurrent modulation of anxiety and memory
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The present results show the influence of kappa receptor modulation on anxiety induction and spontaneous working memory and support the hypothesis that immediate memory processing may modulate the induction of anxiety-related behaviours.
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Although infralimbic quinpirole and sulpiride infusions similarly disrupted alternation performance in the Y-maze and reduced Trial 2 anxiety-like responding in the EPM, these drugs differentially produced these effects.
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The effects of IL infusions of norBNI or pirenzepine alone on anxiety-like behaviour and aversive learning and memory in the elevated plus-maze replicated previously reported data.
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While the IL vmPFC may mediate cautious evaluation of threat situations (risk assessment), the vMO PFC may inhibit prepotent avoidance responses to facilitate such IL-mediated adaptive behavioral responses.
The effects of intra-cerebral drug infusions on animals' unconditioned fear reactions: A systematic review
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The microinfusion data overall give some support for a model of "anxiety" that is functionally segregated along different levels of a neural hierarchy, analogous in some ways to the organization of sensorimotor systems.
Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion
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It is demonstrated that mPFC KORs negatively regulate DA and amino-acid neurotransmission, and are necessary for KOR-mediated aversion.
Modulation of anxiety-related behaviors by μ- and κ-opioid receptor agonists depends on the social status of mice
Abstract This study was aimed to determine the effects of μ- and κ-opioid receptor activation in relation to the social status of mice, being a winner with repeated experience of victories or a loser
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