U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs.

@article{Tao1994U50488BT,
  title={U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs.},
  author={P L Tao and C. L. Hwang and Ching Yu Chen},
  journal={European journal of pharmacology},
  year={1994},
  volume={256 3},
  pages={281-6}
}
U-50,488, (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide hydrochloride), is a selective kappa-opioid receptor agonist. In this study, we found that U-50,488 antagonized morphine-induced antinociception in morphine-naive guinea pigs at doses which did not have any antinociceptive effect by themselves (0.01-3 mg/kg). On the other hand, U-50,488 (3 mg/kg) partially restored morphine-induced antinociception in morphine-tolerant guinea pigs (8 mg/kg/day i.p… CONTINUE READING

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