Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.

  title={Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.},
  author={H Ben-bassat and S Rosenbaum-Mitrani and Z Hartzstark and Rubina Levitzki and Malka Chaouat and Zipora Shlomai and Benjamin Y. Klein and N Kleinberger-Doron and Arnona Gazit and R Tsvieli and Alexander Levitzki},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={290 3},
Human papilloma virus 16 (HPV16) is considered to be the causative agent for cervical cancer, which ranks second to breast cancer in women's malignancies. In an attempt to develop drugs that inhibit the malignant transformation of HPV16-immortalized epithelial cells, we examined the effect of tyrphostins on such cells. We examined the effect of tyrphostins from four different families on the growth of HPV16-immortalized human keratinocytes (HF-1) cells. We found that they alter their cell cycle… CONTINUE READING


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