Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.

@article{Mijovic2002TyrphostinsIL,
  title={Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.},
  author={Jane E Mijovic and Tamas Zakar and Dean B Zaragoza and David M. Olson},
  journal={Journal of perinatal medicine},
  year={2002},
  volume={30 4},
  pages={297-300}
}
OBJECTIVE We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases). STUDY DESIGN The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured. RESULTS Only tyrphostins and NS-398 administered 2 h before LPS successfully delayed preterm birth (p < 0.05… CONTINUE READING

From This Paper

Topics from this paper.
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…