Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.

  title={Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.},
  author={Jane E Mijovic and Tamas Zakar and Dean B Zaragoza and David M. Olson},
  journal={Journal of perinatal medicine},
  volume={30 4},
OBJECTIVE We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases). STUDY DESIGN The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured. RESULTS Only tyrphostins and NS-398 administered 2 h before LPS successfully delayed preterm birth (p < 0.05… CONTINUE READING

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