Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

@article{Nitiss2006TyrosylDNAP,
  title={Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.},
  author={Karin C. Nitiss and Mobeen Malik and Xiaoping He and Stephen W White and John L Nitiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 24},
  pages={
          8953-8
        }
}
Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into DNA-damaging agents, is an essential aspect of cell killing by these drugs. A unique aspect of the repair of topoisomerase-mediated DNA damage is the requirement for pathways that can remove protein covalently bound to DNA. Tyrosyl-DNA phosphodiesterase (Tdp1) is an enzyme that removes phosphotyrosyl moieties bound to the 3' end of DNA. Cells… CONTINUE READING
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