Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface.

@article{DiCostanzo2012TyrosineRM,
  title={Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface.},
  author={Ara Celi DiCostanzo and James R. Thompson and Francis C Peterson and Brian F Volkman and Marina Ram{\'i}rez-Alvarado},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 33},
  pages={27997-8006}
}
Light chain amyloidosis is an incurable protein misfolding disease where monoclonal immunoglobulin light chains misfold and deposit as amyloid fibrils, causing organ failure and death. Previously, we determined that amyloidogenic light chains AL-09 and AL-103 do not form fibrils at pH 10 (tyrosine pK(a)). There are three tyrosine residues (32, 91, and 96… CONTINUE READING