Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p.

@article{Madeo1998TyrosinePR,
  title={Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p.},
  author={Frank Madeo and Jan Schlauer and Hans Zischka and Dieter Mecke and Kai Uwe Fr{\"o}hlich},
  journal={Molecular biology of the cell},
  year={1998},
  volume={9 1},
  pages={131-41}
}
Cdc48p from Saccharomyces cerevisiae and its highly conserved mammalian homologue VCP (valosin-containing protein) are ATPases with essential functions in cell division and homotypic fusion of endoplasmic reticulum vesicles. Both are mainly attached to the endoplasmic reticulum, but relocalize in a cell cycle-dependent manner: Cdc48p enters the nucleus during late G1; VCP aggregates at the centrosome during mitosis. The nuclear import signal sequence of Cdc48p was localized near the amino… CONTINUE READING