Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

@article{Einspahr1991TyrosinePP,
  title={Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.},
  author={K J Einspahr and Robert T. Abraham and Bryce A Binstadt and Yoshimasa Uehara and Paul J. Leibson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 14},
  pages={6279-83}
}
Natural killer (NK) cells are a unique subpopulation of lymphocytes with the capability to kill malignant cells via one of two alternative mechanisms: (i) Fc receptor-dependent cytotoxicity against antibody-coated targets or (ii) direct cell-mediated cytotoxicity. However, the molecular mechanisms that trigger and subsequently regulate NK cell cytotoxicity are incompletely understood. We have therefore investigated the role of protein tyrosine phosphorylation in the transmembrane signaling… CONTINUE READING
29 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…