Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL.

@article{Aten2013TyrosinePO,
  title={Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL.},
  author={Tyler M Aten and Miranda M Redmond and Sheila O Weaver and Collin C Love and Ryan M Joy and Aliya S Lapp and Osvaldo D Rivera and Karen L Hinkle and Bryan A. Ballif},
  journal={FEBS letters},
  year={2013},
  volume={587 15},
  pages={2313-8}
}
A quantitative proteomics screen to identify substrates of the Src family of tyrosine kinases (SFKs) whose phosphorylation promotes CrkL-SH2 binding identified the known Crk-associated substrate (Cas) of Src as well as the orphan receptor endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN). Mutagenesis analysis of ESDN's seven intracellular tyrosines in YxxP motifs found several contribute to the binding of ESDN to the SH2 domains of both CrkCT10 regulator of kinase Crk… CONTINUE READING