Tyrosine phosphorylation of the juxtamembrane domain of the v-Fms oncogene product is required for its association with a 55-kDa protein.

@article{Joos1996TyrosinePO,
  title={Tyrosine phosphorylation of the juxtamembrane domain of the v-Fms oncogene product is required for its association with a 55-kDa protein.},
  author={Hans J{\"u}rgen Joos and Sylvia Trouliaris and G Helftenbein and Heiner Niemann and Taku Tamura},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 40},
  pages={24476-81}
}
Tyrosine autophosphorylation of the v-Fms oncogene product results in the formation of high affinity binding sites for cellular proteins with Src homology 2 (SH2) domains that are involved in various signal cascades. Tryptic digestion of the autophosphorylated v-Fms and of its cellular counterpart, the feline c-Fms polypeptide, gave rise to at least six common major phosphopeptides, four of which have been characterized previously. Employing site-directed mutagenesis and phosphopeptide mapping… CONTINUE READING

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