Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.

@article{Okamura2009TyrosinePO,
  title={Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.},
  author={Tatsunori Okamura and Simendra Singh and John K. Buolamwini and Timothy A. J. Haystead and Henry Friedman and Darell Bigner and Francis R Ali-Osman},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={16979-89}
}
Epidermal growth factor receptor (EGFR) gene amplification, mutations, and/or aberrant activation are frequent abnormalities in malignant gliomas and other human cancers and have been associated with an aggressive clinical course and a poor therapeutic outcome. Elevated glutathione S-transferase P1 (GSTP1), a major drug-metabolizing and stress response signaling protein, is also associated with drug resistance and poor clinical outcome in gliomas and other cancers. Here, we provide evidence… CONTINUE READING