Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells.

  title={Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells.},
  author={Jane L. Ding and Gwendolyn Soule and J. H. Overmeyer and William A Maltese},
  journal={Biochemical and biophysical research communications},
  volume={312 3},
Several members of the large family of Rab GTPases have been shown to function in vesicular trafficking in mammalian cells. However, the exact role of Rab24 remains poorly defined. Rab24 differs from other Rab proteins in that it has a low intrinsic GTPase activity and is not efficiently prenylated. Here we report an additional unique property of Rab24; i.e., the protein can undergo tyrosine phosphorylation when overexpressed in cultured cells. Immunoblot analyses with specific anti… CONTINUE READING


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