Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia.

@article{Guo2002TyrosinePO,
  title={Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia.},
  author={Wei Guo and Shiping Zou and Yun Guan and Tetsuya Ikeda and Michael J. Tal and Ronald Dubner and Ke Ren},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 14},
  pages={6208-17}
}
The present study examined the levels of NMDA receptor NR2 subunit tyrosine phosphorylation in a rat model of inflammation and correlated it with the development of inflammation and hyperalgesia. Hindpaw inflammation and hyperalgesia were induced by intraplantar injection of complete Freund's adjuvant. Proteins from the spinal cord (L4-L5) were immunoprecipitated with anti-NR2A or anti-NR2B antibodies and used for subsequent analysis using 4G-10, a specific anti-phosphotyrosine antibody… CONTINUE READING

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