Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process.

@article{Grangeasse2002TyrosinePO,
  title={Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process.},
  author={Christophe Grangeasse and Patricia Doublet and Alain J. Cozzone},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 9},
  pages={7127-35}
}
In bacteria, several proteins have been shown to autophosphorylate on tyrosine residues, but little is known on the molecular mechanism of this modification. To get more information on this matter, we have analyzed in detail the phosphorylation of a particular autokinase, protein Wzc, from Escherichia coli K12. The analysis of the hydropathic profile of this protein indicates that it is composed of two main domains: an N-terminal domain, including two transmembrane alpha-helices, and a C… CONTINUE READING