Tyrosine phosphorylation of murine Crkl.

  title={Tyrosine phosphorylation of murine Crkl.},
  author={Ron de Jong and Leena Haataja and Jan Willem Voncken and Nora Heisterkamp and John Groffen},
  volume={11 8},
The SH2/SH3 adaptor protein Crkl is abnormally phosphorylated on tyrosine by the Bcr/Abl protein in leukemic cells from patients with Philadelphia-chromosome (Ph)positive leukemia. However, the state of tyrosine-phosphorylation of crkl in normal tissues is unknown. In the current study, we identified mouse crkl by cDNA cloning and examined expression levels and tyrosine-phosphorylation of the mouse crkl protein during embryogenesis and in adult tissues. Tyrosine-phosphorylation of crkl was… CONTINUE READING
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