Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.

@article{Carloni2000TyrosinePO,
  title={Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.},
  author={Vinicio Carloni and Massimo Pinzani and Sabrina Giusti and Roberto Giulio Romanelli and Maurizio Parola and Giacomo Bellomo and Paola Failli and Andrew D. Hamilton and Saı̈d M. Sebti and Giacomo Laffi and Paolo Gentilini},
  journal={Hepatology},
  year={2000},
  volume={31 1},
  pages={131-40}
}
Focal adhesion kinase (FAK) is a widely expressed nonreceptor tyrosine kinase found in focal adhesions. FAK has been indicated as a point of convergence of other signaling pathways including platelet-derived growth factor (PDGF) receptors, and recently, FAK tyrosine phosphorylation has been shown to be stimulated by PDGF. In the present study we assessed the role of Ras as a possible intermediate protein regulating PDGF-induced FAK tyrosine phosphorylation in human hepatic stellate cells (HSCs… CONTINUE READING
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