Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.

@article{Goldberg2002TyrosinePO,
  title={Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.},
  author={Zehavit Goldberg and Ronit Vogt Sionov and Michael Berger and Yaara Zwang and Ruth Perets and Richard A. Van Etten and Moshe Oren and Yoichi Taya and Ygal Haupt},
  journal={The EMBO journal},
  year={2002},
  volume={21 14},
  pages={
          3715-27
        }
}
The p53 tumor suppressor is inhibited and destabilized by Mdm2. However, under stress conditions, this downregulation is relieved, allowing the accumulation of biologically active p53. Recently we showed that c-Abl is important for p53 activation under stress conditions. In response to DNA damage, c-Abl protects p53 by neutralizing the inhibitory effects of Mdm2. In this study we ask whether this neutralization involves a direct interplay between c-Abl and Mdm2, and what is the contribution of… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 84 CITATIONS, ESTIMATED 62% COVERAGE

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

DNA damage response: the emerging role of c-Abl as a regulatory switch?

  • Biochemical pharmacology
  • 2011
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of the nucleus in apoptosis: signaling and execution

VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2003
2018

CITATION STATISTICS

  • 8 Highly Influenced Citations

  • Averaged 2 Citations per year over the last 3 years