Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

@inproceedings{Yoon2014TyrosinePO,
  title={Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs},
  author={Je-Hyun Yoon and Kotb Abdelmohsen and Subramanya Srikantan and Rong Guo and Xiaoling Yang and Jennifer L. Martindale and Myriam Gorospe},
  booktitle={Nucleic acids research},
  year={2014}
}
In response to stress conditions, many mammalian mRNAs accumulate in stress granules (SGs) together with numerous RNA-binding proteins that control mRNA turnover and translation. However, the signaling cascades that modulate the presence of ribonucleoprotein (RNP) complexes in SGs are poorly understood. Here, we investigated the localization of human antigen R (HuR), an mRNA-stabilizing RNA-binding protein, in SGs following exposure to the stress agent arsenite. Unexpectedly, the mobilization… CONTINUE READING
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