Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.

@article{Liu2015TyrosinePO,
  title={Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.},
  author={Tuoen Liu and R. Singh and Zechary Rios and A. Bhushan and M. Li and P. P. Sheridan and Shawn E. Bearden and J. Lai and Senyo Agbenowu and S. Cao and C. K. Daniels},
  journal={Cancer letters},
  year={2015},
  volume={357 1},
  pages={
          231-241
        }
}
  • Tuoen Liu, R. Singh, +8 authors C. K. Daniels
  • Published 2015
  • Medicine, Biology
  • Cancer letters
  • We previously identified and characterized a 66-68 kDa membrane-associated, tyrosine phosphorylated protein in murine leukemia L1210 cells as HSC70 which is a methotrexate (MTX)-binding protein. In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210 cells, we first showed that HSC70 colocalizes and interacts with reduced folate carrier (RFC) in L1210 cells by confocal laser scanning microscopy and Duolink in situ proximity ligation assay. The… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
    • 40
    • PDF
    Heat Shock Proteins and Cancer.
    • 169
    Identification of GdRFC1 as a novel regulator of telomerase in Giardia duodenalis
    Heat Shock Protein 70 and Cancer
    • 1
    DNLC: differential network local consistency analysis

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 54 REFERENCES
    Human reduced folate carrier: translation of basic biology to cancer etiology and therapy
    • 214