Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.

@article{Liu2015TyrosinePO,
  title={Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.},
  author={Tuoen Liu and R. Singh and Zechary Rios and A. Bhushan and M. Li and P. P. Sheridan and Shawn E. Bearden and J. Lai and Senyo Agbenowu and S. Cao and C. K. Daniels},
  journal={Cancer letters},
  year={2015},
  volume={357 1},
  pages={
          231-241
        }
}
  • Tuoen Liu, R. Singh, +8 authors C. K. Daniels
  • Published 2015
  • Biology, Medicine
  • Cancer letters
  • We previously identified and characterized a 66-68 kDa membrane-associated, tyrosine phosphorylated protein in murine leukemia L1210 cells as HSC70 which is a methotrexate (MTX)-binding protein. In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210 cells, we first showed that HSC70 colocalizes and interacts with reduced folate carrier (RFC) in L1210 cells by confocal laser scanning microscopy and Duolink in situ proximity ligation assay. The… CONTINUE READING
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