Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.

@article{Haines2009TyrosinePO,
  title={Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.},
  author={Eric Haines and Parham Minoo and Zhenqian Feng and Nazila Resalatpanah and Xin-min Nie and Manuela Campiglio and Laura Alvarez and Eftihia Cocolakis and Mohammed Ridha and Mauricio Di Fulvio and Julian Gomez-Cambronero and J L Lebrun and Suhad A. Ali},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 10},
  pages={2505-20}
}
Characterizing mechanisms regulating mammary cell growth and differentiation is vital, as they may contribute to breast carcinogenesis. Here, we examine a cross talk mechanism(s) downstream of prolactin (PRL), a primary differentiation hormone, and epidermal growth factor (EGF), an important proliferative factor, in mammary epithelial cell growth and differentiation. Our data indicate that EGF exerts inhibitory effects on PRL-induced cellular differentiation by interfering with Stat5a-mediated… CONTINUE READING

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