Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z.

@article{Fujikawa2007TyrosinePO,
  title={Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z.},
  author={Akihiro Fujikawa and Jeremy Pak Hong Chow and Hidetada Shimizu and Masahide Fukada and Ryoko Suzuki and Masaharu Noda},
  journal={Journal of biochemistry},
  year={2007},
  volume={142 3},
  pages={343-50}
}
Protein tyrosine phosphatase receptor type Z (Ptprz/PTPzeta/RPTPbeta) is a receptor-like protein tyrosine phosphatase (RPTP) preferentially expressed in the brain. ErbB4 is a member of the ErbB-family tyrosine kinases known as a neuregulin (NRG) receptor. Both are known to bind to postsynaptic density-95 (PSD95) on the second and the first/second PDZ (PSD95/Disc large/zona occludens1) domains, respectively, through the PDZ-binding motif of their carboxyl termini. Here we report a functional… CONTINUE READING

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