Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

@article{Kaplan1991TyrosinePA,
  title={Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF},
  author={D. Kaplan and D. Mart{\'i}n-Zanca and L. Parada},
  journal={Nature},
  year={1991},
  volume={350},
  pages={158-160}
}
NERVE growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory neurons as well as selective populations of cholinergic neurons1,2. NGF binds to specific cell-surface receptors but the mechanism for transduction of the neurotrophic signal is unknown. Several experiments using the NGF-responsive pheochromocytoma cell line, PC12, have implicated tyrosine phosphorylation in NGF-mediated responses, although no NGF-specific tyrosine… Expand
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