Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

@article{Kaplan1991TyrosinePA,
  title={Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF},
  author={D. Kaplan and D. Mart{\'i}n-Zanca and L. Parada},
  journal={Nature},
  year={1991},
  volume={350},
  pages={158-160}
}
  • D. Kaplan, D. Martín-Zanca, L. Parada
  • Published 1991
  • Biology, Medicine
  • Nature
    • NERVE growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory neurons as well as selective populations of cholinergic neurons1,2. NGF binds to specific cell-surface receptors but the mechanism for transduction of the neurotrophic signal is unknown. Several experiments using the NGF-responsive pheochromocytoma cell line, PC12, have implicated tyrosine phosphorylation in NGF-mediated responses, although no NGF-specific tyrosine… CONTINUE READING
    View on Nature
    ncbi.nlm.nih.gov
    955 Citations
    Highly Influential Citations
    32
    Background Citations
    214
    Methods Citations
    16
    Results Citations
    5
    955 Citations
    Citation Type

    Citation Type

    Specific inhibition of NGF receptor tyrosine kinase activity by K-252a.
    • 14
    The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
    • 491
    Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.
    • S. Meakin, E. Shooter
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1991
    • 54
    • PDF
    Neurotrophin signal transduction by the Trk receptor.
    • 528
    Studying signal transduction in neuronal cells: the Trk/NGF system.
    • D. Kaplan
    • Biology, Medicine
    • Progress in brain research
    • 1998
    • 41
    The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.
    • 129
    • PDF
    TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells
    • 59
    Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
    • 313
    Specificity of nerve growth factor signaling: Differential patterns of early tyrosine phosphorylation events induced by NGF, EGF, and bFGF
    • 19
    Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
    • 123
    • PDF

    References

    SHOWING 1-10 OF 18 REFERENCES
    Nerve growth factor induces protein-tyrosine phosphorylation.
    • P. Maher
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1988
    • 144
    • PDF
    Role of protein tyrosine phosphorylation in the NGF response
    • P. Maher
    • Biology, Medicine
    • Journal of neuroscience research
    • 1989
    • 42
    Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor
    • 314
    trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
    • 556
    PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
    • 327
    Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.
    • 321
    • PDF
    Molecular and biochemical characterization of the human trk proto-oncogene.
    • 534
    • PDF
    Tyrosine phosphorylations in vivo associated with v-fms transformation.
    • 31
    • PDF
    Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.
    • 442
    • PDF
    Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line
    • 241