Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

@article{Kaplan1991TyrosinePA,
  title={Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF},
  author={David R Kaplan and Dionisio Mart{\'i}n-Zanca and Luis F. Parada},
  journal={Nature},
  year={1991},
  volume={350},
  pages={158-160}
}
NERVE growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory neurons as well as selective populations of cholinergic neurons1,2. NGF binds to specific cell-surface receptors but the mechanism for transduction of the neurotrophic signal is unknown. Several experiments using the NGF-responsive pheochromocytoma cell line, PC12, have implicated tyrosine phosphorylation in NGF-mediated responses, although no NGF-specific tyrosine… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 240 extracted citations

Two Peptides Derived from the Nerve Growth Factor Precursor Are Biologically Active

The Journal of cell biology • 1997
View 4 Excerpts
Highly Influenced

Regulation of the Neuronal Chloride Cotransporter KCC 2 by Neurotrophins

Judith Thomas Crusells
2004
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…