Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.

@article{Rao2002TyrosinePA,
  title={Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.},
  author={RadhaKrishna Rao and Shyamali Basuroy and V. Umamaheshwar Rao and Karl John Karnaky and Akshay R. Gupta},
  journal={The Biochemical journal},
  year={2002},
  volume={368 Pt 2},
  pages={
          471-81
        }
}
The oxidative-stress-induced alteration in paracellular junctional complexes was analysed in Caco-2 cell monolayer. Oxidative stress induced a rapid increase in tyrosine phosphorylation of occludin, zonula occludens (ZO)-1, E-cadherin and beta-catenin. An oxidative-stress-induced decrease in transepithelial electrical resistance was associated with a redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the intercellular junctions. Genistein, a tyrosine kinase inhibitor… CONTINUE READING
135 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin

  • F. Trischitta, M. G. Donaro, C. Faggo, M. G. Lionetto
  • Cell Reg
  • 2001

Similar Papers

Loading similar papers…