Tyrosine phosphorylation and CD95: a FAScinating switch.

  title={Tyrosine phosphorylation and CD95: a FAScinating switch.},
  author={Ignacio Sancho-Martinez and Ana Martin-Villalba},
  journal={Cell cycle},
  volume={8 6},
Apoptosis or programmed cell-death is an important process involved in tissue homeostasis, development and a variety of immune responses.(1) The apoptotic program can be activated via transmembrane receptors stimulated by their cognate ligands. The presence of a well-conserved region of 80 amino acids in their intracellular tail, the Death-Domain (DD), has conferred those receptors the general name of "death receptors". Death receptors are a subfamily of the TNF receptor superfamily, which… CONTINUE READING


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