Tyrosine phosphorylation–dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis

@inproceedings{Kanda2011TyrosinePA,
  title={Tyrosine phosphorylation–dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis},
  author={Shoichiro Kanda and Yutaka Harita and Yoshio Shibagaki and Takashi Sekine and Takashi Igarashi and Takafumi Inoue and Seisuke Hattori},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Transient receptor potential canonicals (TRPCs) play important roles in the regulation of intracellular calcium concentration. Mutations in the TRPC6 gene are found in patients with focal segmental glomerulosclerosis (FSGS), a proteinuric disease characterized by dysregulated function of renal glomerular epithelial cells (podocytes). There is as yet no clear picture for the activation mechanism of TRPC6 at the molecular basis, however, and the association between its channel activity and… CONTINUE READING

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