Tyrosine-phosphorylated bacterial effector proteins: the enemies within.

  title={Tyrosine-phosphorylated bacterial effector proteins: the enemies within.},
  author={Steffen Backert and Matthias Selbach},
  journal={Trends in microbiology},
  volume={13 10},
The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp… CONTINUE READING

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