Tyrosine-phosphorylated bacterial effector proteins: the enemies within.


The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.

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@article{Backert2005TyrosinephosphorylatedBE, title={Tyrosine-phosphorylated bacterial effector proteins: the enemies within.}, author={Steffen Backert and Matthias Selbach}, journal={Trends in microbiology}, year={2005}, volume={13 10}, pages={476-84} }