Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

@article{Deng2015TyrosinePS,
  title={Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses},
  author={Zihou Deng and Shixin Ma and Hao Zhou and Aiping Zang and Yiyuan Fang and Tiantian Li and Huanjing Shi and Mei Liu and Min Du and Patricia R. Taylor and Helen He Zhu and Jiangye Chen and Guangxun Meng and Fubin Li and Changbin Chen and Yan Zhang and Xin-Ming Jia and Xin Lin and Xiaoming Zhang and Eric Pearlman and Xiaoxia Li and Gen-sheng Feng and Hui Xiao},
  journal={Nature Immunology},
  year={2015},
  volume={16},
  pages={642-652}
}
Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired Syk-mediated signaling and abrogated the expression of genes encoding pro-inflammatory molecules following fungal stimulation… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X.J
  • J. Biol. Chem. 290,
  • 2015

Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2

Taylor, P.R
  • Nat. Immunol
  • 2014

Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis

Huppler, A.R
  • J. Immunol
  • 2014

Interferon-beta production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans

C del Fresno
  • Immunity 38,
  • 2013

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

W Yang
  • Nature 499,
  • 2013

to C . albicans

A. R. Huppler
  • 2013

Similar Papers

Loading similar papers…