Tyrosine kinases open lymphocyte chloride channels.

  title={Tyrosine kinases open lymphocyte chloride channels.},
  author={Albrecht Lepple-Wienhues and Ildik{\'o} Kurit{\'a}rn{\'e} Szab{\'o} and Ute Wieland and Luke H Heil and Erich Gulbins and Florian Lang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={10 5-6},
Osmotic swelling of lymphocytes opens outwardly rectifying Cl(-) channels (ORCC) through the src-like kinase p56(lck). The central role of this tyrosine protein kinase has been shown by genetic and pharmacologic manipulation of the enzyme. Furthermore, p56(lck) activates ORCC independently of cell volume increase. ORCC in lymphocytes and epithelial cells from cystic fibrosis (CF) patients are resistant to activation by cAMP. However, osmotic swelling as well as intracellular purified p56(lck… CONTINUE READING
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