Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

@article{Takata1994TyrosineKL,
  title={Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.},
  author={Minoru Takata and H. Sabe and Akiko Hata and Tetsuya Inazu and Yoshimi Homma and Toshihide Nukada and Hirohei Yamamura and Tomohiro Kurosaki},
  journal={The EMBO journal},
  year={1994},
  volume={13 6},
  pages={1341-9}
}
Stimulation of B lymphocytes through their antigen receptor (BCR) results in rapid increases in tyrosine phosphorylation on a number of proteins and induces both an increase of phosphatidylinositol and mobilization of cytoplasmic free calcium. The BCR associates with two classes of tyrosine kinase: Src-family kinase (Lyn, Fyn, Blk or Lck) and Syk kinase. To dissect the functional roles of these two types of kinase in BCR signaling, lyn-negative and syk-negative B cell lines were established… CONTINUE READING
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