Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease

@article{Scheijen2002TyrosineKO,
  title={Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease},
  author={Blanca Scheijen and James D Griffin},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={3314-3333}
}
Tyrosine kinase oncogenes are formed as a result of mutations that induce constitutive kinase activity. Many of these tyrosine kinase oncogenes that are derived from genes, such as c-Abl, c-Fes, Flt3, c-Fms, c-Kit and PDGFRβ, that are normally involved in the regulation of hematopoiesis or hematopoietic cell function. Despite differences in structure, normal function, and subcellular location, many of the tyrosine kinase oncogenes signal through the same pathways, and typically enhance… CONTINUE READING
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