Tyrosine kinase inhibitors and modifications of thyroid function tests: a review.

@article{Illouz2009TyrosineKI,
  title={Tyrosine kinase inhibitors and modifications of thyroid function tests: a review.},
  author={Fr{\'e}d{\'e}ric Illouz and Sandrine Laboureau-Soares and Severine Dubois and Vincent Rohmer and Patrice Rodien},
  journal={European journal of endocrinology},
  year={2009},
  volume={160 3},
  pages={331-6}
}
Tyrosine kinase inhibitors (TKI) belong to new molecular multi-targeted therapies that are approved for the treatment of haematological and solid tumours. They interact with a large variety of protein tyrosine kinases involved in oncogenesis. In 2005, the first case of hypothyroidism was described and since then, some data have been published and have confirmed that TKI can affect the thyroid function tests (TFT). This review analyses the present clinical and fundamental findings about the… CONTINUE READING

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