Tyrosine kinase inhibitors: from rational design to clinical trials.

  title={Tyrosine kinase inhibitors: from rational design to clinical trials.},
  author={Peter Traxler and Guido Bold and Elisabeth Buchdunger and Giorgio Caravatti and Pascal Furet and Paul Manley and Terence M O'Reilly and James Wood and Juerg Zimmermann},
  journal={Medicinal research reviews},
  volume={21 6},
Protein kinases play a crucial role in signal transduction as well as in cellular proliferation, differentiation, and various regulatory mechanisms. The inhibition of growth related kinases, especially tyrosine kinases, might provide new therapies for diseases such as cancer. The progress made in the crystallization of protein kinases has confirmed that the ATP-binding domain of tyrosine kinases is an attractive target for drug design. Three successful examples of drug design at Novartis using… CONTINUE READING


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