Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.

@article{Fukumoto1996TyrosineKI,
  title={Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.},
  author={Yoshihiro Fukumoto and Hiroaki Shimokawa and Toshiyuki Kozai and Toshiaki Kadokami and Kouichi Kuwata and Michitaka Owada and Takahiro Shiraishi and Takeshi Kuga and Kensuke Egashira and Akira Takeshita},
  journal={Cardiovascular research},
  year={1996},
  volume={32 6},
  pages={1131-40}
}
OBJECTIVE Restenosis after percutaneous transluminal coronary angioplasty (PTCA) still remains a serious late complication. Many growth factors induced in restenotic lesions may be responsible for restenosis after PTCA. Most of the receptors for such growth factors possess tyrosine kinase activity. This study was designed to determine whether or not a specific tyrosine kinase inhibitor, ST 638, can prevent (re)stenotic changes of the coronary artery after balloon injury. METHODS A segment of… CONTINUE READING

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