Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice.

@article{Yamaki2012TyrosineKI,
  title={Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice.},
  author={Kouya Yamaki and Shin Yoshino},
  journal={Allergy},
  year={2012},
  volume={67 1},
  pages={114-22}
}
BACKGROUND   Systemic and oral antigen-induced anaphylaxes are mediated by immunoglobulin (Ig) E and mast cells, but there is no satisfactory treatment for the life-threatening allergic reaction. We investigated the potential of the multitargeted receptor tyrosine kinase inhibitor sunitinib to relieve anaphylactic reactions in food allergy and systemic anaphylaxis. METHODS   Efficacy of oral sunitinib on oral and parenteral antigen-induced anaphylaxes in Balb/c mice was evaluated. IgE… CONTINUE READING
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Mast cells Yamaki and Yoshino Sunitinib relieves food allergy in mice

  • EB Brandt, RT Strait, D Hershko, Q Wang, EE Muntel, TA Scribner
  • Allergy
  • 2012
Highly Influential
4 Excerpts

previously undefined side effects with therapeutic potential

  • K Eechoute, M van Zonneveld, PL van Daele, R Gerth van Wijk, rhinitis Mathijssen RH. Suppressing effects of sunitinib on allergic
  • J Clin Pharmacol 2010; doi: 10.1177/00912700…
  • 2012
1 Excerpt

pressing effects of sunitinib on allergic rhinitis : previously undefined side effects with therapeutic potential

  • K Eechoute, M vanZonneveld, R GerthvanWijk, RH Mathijssen
  • J Clin Pharmacol
  • 2010

Inhibitory effects of sunitinib on ovalbumin-induced chronic experimental asthma in mice

  • H Mao, L Xuan, D Qiang, Y Xin, Y. Kaisheng
  • Chin Med J
  • 2009
1 Excerpt

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