Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters.

  title={Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters.},
  author={Csilla Ozvegy-Laczka and Judit Cserepes and N. Barry Elkind and Bal{\'a}zs Sarkadi},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={8 1-2},
Recent antitumor drug research has seen the development of a large variety of tyrosine kinase inhibitors (TKIs) with increasing specificity and selectivity. These are highly promising agents for specific inhibition of malignant cell growth and metastasis. However, their therapeutic potential also depends on access to their intracellular targets, which may be significantly affected by certain ABC membrane transporters. It has been recently shown that several human multidrug transporter ABC… CONTINUE READING


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