Tyrosine kinase inhibitor as a therapeutic drug for chronic myelogenous leukemia and gastrointestinal stromal tumor.

@article{Nakajima2003TyrosineKI,
  title={Tyrosine kinase inhibitor as a therapeutic drug for chronic myelogenous leukemia and gastrointestinal stromal tumor.},
  author={Motowo Nakajima and Wakako Toga},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={2003},
  volume={122 6},
  pages={
          482-90
        }
}
  • M. Nakajima, W. Toga
  • Published 1 December 2003
  • Biology, Chemistry
  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
The Philadelphia chromosome found in leukemia cells of chronic myelogenous leukemia (CML) patients is produced by translocation between chromosomes 9 and 22, resulting in expression of a chimera protein of Bcr and Abl kinase in the cytoplasm. Bcr-Abl kinase attracted oncology researchers as a molecular target for CML therapy, and a variety of small Abl kinase inhibitors were synthesized. STI571 (imatinib mesylate) was produced by modification of 2-phenylaminopyrimidine, a core structure of… 
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1Pharmaceutical Science Department, Faculty of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia, 2Pharmaceutical Practice Department, Faculty of Pharmacy, Princess Nourah

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