Tyrosine kinase gene rearrangements in epithelial malignancies

@article{Shaw2013TyrosineKG,
  title={Tyrosine kinase gene rearrangements in epithelial malignancies},
  author={Alice Tsang Shaw and Peggy P. Hsu and Mark M. Awad and Jeffrey A. Engelman},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={772-787}
}
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in many epithelial cancers. These cancers express activated fusion kinases that drive the initiation and progression of malignancy, and often have a considerable response to small-molecule kinase inhibitors, which validates these fusion kinases as 'druggable' targets. In this Review, we examine the aetiologic, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases… CONTINUE READING

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In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
In this Review , we examine the aetiologic , pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases , including anaplastic lymphoma kinase ( ALK ) , ROS1 and RET .
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