Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

  title={Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel},
  author={Max L. Schiff and David P. Siderovski and Jacqueline D. Jordan and Greg M. Brothers and Bryan E. Snow and Luc De Vries and Daniel F. Ortiz and Mar{\'i}a A Divers{\'e}-Pierluissi},
γ-Aminobutyric acid (GABA)B receptors couple to G o to inhibit N-type calcium channels in embryonic chick dorsal root ganglion neurons. The voltage-independent inhibition, mediated by means of a tyrosine-kinase pathway, is transient and lasts up to 100 seconds. Inhibition of endogenous RGS12, a member of the family of regulators of G-protein signalling, selectively alters the time course of voltage-independent inhibition. The RGS12 protein, in addition to the RGS domain, contains PDZ and PTB… CONTINUE READING


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