Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis.

@article{Dastych1998TyrosineKW,
  title={Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis.},
  author={Jaroslaw Dastych and Dennis D. Taub and Mary C Hardison and Dean D Metcalfe},
  journal={The American journal of physiology},
  year={1998},
  volume={275 5 Pt 1},
  pages={C1291-9}
}
W/Wv mice are deficient in tissue mast cells, and mast cells cultured from these mice do not proliferate in response to the c-kit ligand, stem cell factor (SCF). In this paper, we report that mouse bone marrow cultured mast cells derived from W/Wv mice do adhere to fibronectin in the presence of SCF and exhibit chemotaxis to SCF, and we explore this model… CONTINUE READING