Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

@article{Nicholson1994TyrosineKJ,
  title={Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.},
  author={Sandra E Nicholson and Andrew C Oates and Ailsa G. Harpur and Andrew Ziemiecki and Andrew F. Wilks and Judith E. Layton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 8},
  pages={2985-8}
}
Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage by interaction with a specific receptor. Early signal transduction events following G-CSF receptor activation were studied. We detected tyrosine phosphorylation of both the G-CSF receptor and the protein tyrosine kinase JAK1… CONTINUE READING