Tyrosine kinase, phosphatidylinositol 3-kinase, and protein kinase C regulate insulin-stimulated NaCl absorption in the thick ascending limb.

@article{Ito1997TyrosineKP,
  title={Tyrosine kinase, phosphatidylinositol 3-kinase, and protein kinase C regulate insulin-stimulated NaCl absorption in the thick ascending limb.},
  author={Osamu Ito and Yoshiaki Kondo and Mikiko Oba and Naofumi Takahashi and Kazumi Omata and Keishi Abe},
  journal={Kidney international},
  year={1997},
  volume={51 4},
  pages={1037-41}
}
We have previously shown a direct stimulatory effect of insulin on NaCl absorption in the medullary thick ascending limb of Henle's loop (mTAL). To further investigate the signal transduction involved, we determined whether tyrosine kinase, phosphatidylinositol 3-kinase (PI3-kinase), and/or protein kinase C (PKC) regulate insulin-stimulated NaCl absorption in the mTAL by in vitro microperfusion methods. In control experiments, insulin increased transepithelial voltage (V(te)) and net lumen-to… CONTINUE READING

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