Tyrosine hydroxylase regulation in the central nervous system
@article{Masserano2004TyrosineHR, title={Tyrosine hydroxylase regulation in the central nervous system}, author={Joseph M. Masserano and Norman D. Weiner}, journal={Molecular and Cellular Biochemistry}, year={2004}, volume={53-54}, pages={129-152} }
SummaryTyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alterations in tyrosine hydroxylase activity in the central nervous system. In many of these instances, the changes in the activity of tyrosine hydroxylase in the central…
49 Citations
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The L5178Y-R lymphoma does not express Th during in vivo progression, suggesting a broader role for cathecholamines in lymphocyte function, as well as the potential secretion of catecholamines by tumors of lymphoid origin.
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Progesterone Induces Dephosphorylation and Inactivation of Tyrosine Hydroxylase in Rat Hypothalamic Dopaminergic Neurons
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Examination of the acute inhibitory action of progesterone on TH activity in rat fetal hypothalamic dopaminergic neurons in vitro indicates that the acute progester one-induced decline in TH activity is caused by dephosphorylation of TH.
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- Biology, ChemistryEndocrine
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The data suggest that protein dephosphorylation may be a primary mechanism for the rapid BROMO-dependent suppression of tyrosine hydroxylase activity, whereas suppressed gene expression may contribute to the lower tyrosin hydroxyase activity after chronicBROMO treatment.
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Data indicate that calmodulin and a cyclic nucleotide-dependentprotein kinase contribute to the PRL-induced increase in tyrosine hydroxylase activity, but the role of calcium/calmodulin-dependent protein kinase II is still unclear.
Individual Differences in the Expression of Tyrosine Hydroxylase mRNA in Neurosecretory Neurons of the Human Paraventricular and Supraoptic Nuclei: Positive Correlation with Vasopressin mRNA
- BiologyNeuroendocrinology
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It is shown that the individual variability in the number of TH-IR neurons within the neurosecretory nuclei might be due to differential expression and/or stability of TH mRNA and that expression of Th-immunoreactivity in human PVN and SON depends on the activation of VP neurons.
References
SHOWING 1-10 OF 180 REFERENCES
Catecholamine synthesizing enzymes in brain stem and hypothalamus during the development of renovascular hypertension
- BiologyBrain Research
- 1979
Prolonged activation of tyrosine hydroxylase in noradrenergic neurones of rat brain by cholinergic stimulation
- Biology, ChemistryNature
- 1975
The trans-synaptically mediated increase in TH activity is due to excitation of cholinergic receptors, occurs after a latency of many hours to days, remains elevated up to weeks and is attributable entirely to increased accumulation of TH enzyme molecules; it therefore represents induction of the enzyme.
Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine.
- Biology, ChemistryScience
- 1980
A novel form of plasticity in brain-damaged animals characterized by an increase in the capacity for transmitter biosynthesis in residual neurons is suggested by an increases in tyrosine hydroxylase activity and norepinephrine synthesis rate.
Reversible changes in the activities of tyrosine hydroxylase and dopamine-β-hydroxylase in neurons of the nucleus locus coeruleus after experimental stroke
- BiologyExperimental Neurology
- 1981
Induction of Tyrosine Hydroxylase in Peripheral and Central Adrenergic Neurones by Cold-exposure of Rats
- Biology, ChemistryNature
- 1970
This study shows that prolonged exposure of rats to cold provokes an increase in the in vitro tyrosine hydroxylase activity not only in peripheral sympathetic ganglia and adrenal medulla, but also in parts of the central nervous system.
Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock.
- Biology, ChemistryProceedings of the National Academy of Sciences of the United States of America
- 1969
A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive…
The regulation of striatal tyrosine hydroxylase
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
Results suggest that in striatal dopaminergic terminals the Kmof TH for the pteridine cofactor is regulated by an molecular mechanism which requires that the impulse flow in the DA neurons is unimpaired.
Increase in tyrosine hydroxylase activity after reserpine administration.
- Biology, MedicineThe Journal of pharmacology and experimental therapeutics
- 1969
It is suggested that prolonged periods of drug-induced sympathoadrenal hyperactivity can increase the amount of tyrosine hydroxylase in adrenergic areas of the central and peripheral nervous systems.
Changes in Central Catecholaminergic Neurons in the Spontaneously (Genetic) Hypertensive Rat
- BiologyCirculation research
- 1978
These results implicate adrenergic neurons in the brainstem and noradrenergic neuron in the hypothalamus in the development of spontaneous (genetic) hypertension in rats.
MOUSE BRAIN TYROSINE HYDROXYLASE AND GLUTAMIC ACID DECARBOXYLASE FOLLOWING TREATMENT WITH ADRENOCORTICOTROPHIC HORMONE, VASOPRESSIN OR CORTICOSTERONE
- BiologyJournal of neurochemistry
- 1978
No changes in the activity of either TH or GAD were observed in any brain region following repeated administration of adrenocorticotrophic hormone, lysine vasopressin or corticosterone, which suggests that the changes of catecholamine turnover are not mediated by changes of TH activity.