Tyrosine hydroxylase regulation in the central nervous system

@article{Masserano2004TyrosineHR,
  title={Tyrosine hydroxylase regulation in the central nervous system},
  author={Joseph M. Masserano and Norman D. Weiner},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={53-54},
  pages={129-152}
}
SummaryTyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alterations in tyrosine hydroxylase activity in the central nervous system. In many of these instances, the changes in the activity of tyrosine hydroxylase in the central… 
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