Tyrosine hydroxylase activity increases in pineal sympathetic nerves after depletion of neuronal serotonin

@article{Rubio1977TyrosineHA,
  title={Tyrosine hydroxylase activity increases in pineal sympathetic nerves after depletion of neuronal serotonin},
  author={Modesto Carlos Rubio and Guillermo Jaim-Etcheverry and Luis Mar{\'i}a Zieher},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1977},
  volume={301},
  pages={75-78}
}
The injection of p-chlorophenylalanine (PCPA) acutely reduced serotonin in the pineal gland of the rat and selectively elevated the noradrenaline (NA) content during the subsequent 24 h. The activity of tyrosine hydroxylase (TH) also increased in intact glands during the first 6 h after PCPA injection but returned to normal at 24 h. This enhancement of… CONTINUE READING