Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress.

@article{Fluharty1985TyrosineHA,
  title={Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress.},
  author={Steven J. Fluharty and Gretchen L. Snyder and Michael J. Zigmond and Edward M. Stricker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={233 1},
  pages={32-8}
}
Chronic hypotension and hypoglycemia are known to increase the capacity for catecholamine biosynthesis in the rat adrenal medulla by increasing the maximal velocity of the rate-limiting enzyme, tyrosine hydroxylase (TH). The present report indicates that the gradual increase in maximal TH activity is preceded by a more rapid increase in the affinity of TH for its pterin cofactor. These short-term alterations in adrenal TH activity are related to the severity of the stress, associated with… CONTINUE READING

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